ABSTRACT
Objective: To evaluate in experimental animals the changes of the palpebral fissure and the orbital volume after orbital injection of bimatoprost 0.03%. Methods: Two main groups of Wistar rats were analyzed, one after orbital injection of bimatoprost 0.03% and another, a control group, after orbital injection of saline solution. The calculation of the palpebral fissure was done on images by means of computer processing, using the program Image J. After taking photographs, the animals were submitted to bilateral orbital exenteration and the volume was calculated in all the animals by the water displacement method (Archimedes’ Principle). Results: While comparing the measurements of the palpebral fissure and the orbital volume among animals given an injection with bimatoprost 0.03% and the control group it was found that there were no statistically significant differences. Conclusions: In this study there were no statistically significant differences in the measurement of the vertical palpebral fissure and the orbital volume among animals given the orbital injection of bimatoprost 0.03% and the animals of the control group. .
Objetivo: Avaliar em modelos experimentais as alterações da fenda palpebral e do volume orbitário após aplicação orbitária de bimatoprost 0,03%. Métodos: Dois principais grupos compostos por ratos Wistar foram analisados, sendo comparados os animais submetidos à injeção orbitária de bimatoprost 0.03% com os submetidos à injeção orbitária de solução salina. O cálculo da fenda palpebral vertical foi obtido através de imagem computadorizada utilizando-se o programa Image J. Após serem fotografados os animais foram submetidos à exenteração bilateral e o volume orbitário foi calculado pelo método de deslocamento da coluna de água (Princípio de Archimedes). Resultados: Quando foram comparadas as medidas da fenda palpebral vertical e do volume orbitário entre os animais submetidos a injeção de bimatoprost 0.03% e o grupo controle não foi obsevada diferença estatisticamente significante. Conclusão: Neste estudo não houve diferença estatisticamente significante nas medidas da fenda palpebral vertical e no volume orbitário entre os animais submetidos à injeção orbitária de bimatoprost 0.03% e o grupo controle. .
Subject(s)
Animals , Male , Orbit/drug effects , Atrophy/chemically induced , Adipose Tissue/drug effects , Eyelids/drug effects , Bimatoprost/adverse effects , Bimatoprost/pharmacology , Orbital Diseases/chemically induced , Prostaglandins F, Synthetic/administration & dosage , Prostaglandins F, Synthetic/adverse effects , Prostaglandins F, Synthetic/pharmacology , Rats , Rats, Wistar , Adipocytes/drug effects , Eyelid Diseases/chemically induced , Injections, IntraocularABSTRACT
Relata-se o caso de reação local após injeção subtenoniana profunda de1 ml de suspensão contendo 40 mg de triancinolona, realizada em uma criança de seis anos de idade, portadora de uveíte intermediária. Observou-se edema e eritema das pálpebras superior e inferior, aproximadamente 30 minutos após a injeção. Houve recuperação completa, sem complicações, ao longo das 24 a 48 horas seguintes.
A case of a local reaction related to a subtenonian deep injection of triamcinolone is reported. The patient was a 6 year old child, with intermediate uveitis. Intense edema and erythema of the eyelids appeared approximately 30 minutes after the injection. Complete resolution occurred among 24 to 48 hours after the injection.
Subject(s)
Child , Humans , Male , Drug Eruptions/etiology , Glucocorticoids/adverse effects , Triamcinolone/adverse effects , Uveitis, Intermediate/drug therapy , Edema/chemically induced , Erythema/chemically induced , Eyelid Diseases/chemically induced , Glucocorticoids/administration & dosage , Injections/methods , Triamcinolone/administration & dosageSubject(s)
Adult , Dermatitis, Allergic Contact/diagnosis , Drug Eruptions/diagnosis , Eyelid Diseases/chemically induced , Female , Humans , Mydriatics/administration & dosage , Ophthalmic Solutions/adverse effects , Patch Tests , Phenylephrine/administration & dosage , Presbyopia/drug therapy , Skin/pathology , Sympathomimetics/administration & dosageABSTRACT
We present our two-year experience in the management of chemical burns involving the eyelids. The series includes patients with eyelid burns as well as those presenting with post-burn eyelid contractures. Majority of the patients were victims of homicidal incidents with females outnumbering the males. In all patients, the involved eyelids were treated simultaneously by release of contracture and skin grafting. The fibrous tissue response has been observed to be more rapid and florid in chemical burns as compared to flame burns. Early, aggressive intervention is required to prevent serious sequelae which may follow chemical burns of the eyelids